abstract：:Mechanical ventilation is a life-support therapy for intensive care patients suffering from respiratory failure. To reduce the current rate of ventilator-induced lung injury requires ventilator settings that are patient-, time-, and disease-specific. A common lung protective strategy is to optimise the level of positi...

journal_title：Annals of biomedical engineering

authors： Morton SE,Knopp JL,Chase JG,Möller K,Docherty P,Shaw GM,Tawhai M

更新日期：2019-07-01 00:00:00

abstract：:Irreversible electroporation (IRE), is a new non-thermal tissue ablation technology in which brief high electric field pulses are delivered across the target tissue to induce cell death by irreversible permeabilization of the cell membrane. A deficiency of conventional IRE is that the ablation zone is relatively small...

journal_title：Annals of biomedical engineering

authors： Lv Y,Yao C,Rubinsky B

更新日期：2019-07-01 00:00:00

abstract：:The efforts to develop structural materials for biodegradable metal implants have lately shifted their focus from Magnesium and Iron base alloys towards Zinc. This was mainly due to the accelerated corrosion rate of Mg that is accompanied by hydrogen gas evolution, formation of voluminous iron oxide products with redu...

journal_title：Annals of biomedical engineering

authors： Kafri A,Ovadia S,Yosafovich-Doitch G,Aghion E

更新日期：2019-06-01 00:00:00

abstract：:Neuromuscular impairment associated with cerebral palsy (CP) often leads to life-long walking deficits. Our goal was to evaluate the ability of a novel untethered wearable ankle exoskeleton to reduce the severity of gait pathology from CP. In this clinical feasibility study of five individuals with CP, we used instrum...

journal_title：Annals of biomedical engineering

authors： Lerner ZF,Harvey TA,Lawson JL

更新日期：2019-06-01 00:00:00

abstract：:The bioinspired, microscale tissue engineering approach has emerged in recent years as a promising alternative to preformed scaffolds. Using this approach, complex tissues and organs can be efficiently engineered from microscale modules to replicate the intricate architecture and physiology of vascularized organs and ...

journal_title：Annals of biomedical engineering

authors： Annamalai RT,Matthew HWT

更新日期：2019-05-01 00:00:00

abstract：:Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective ...

journal_title：Annals of biomedical engineering

authors： Mononen ME,Liukkonen MK,Korhonen RK

更新日期：2019-03-01 00:00:00

abstract：:Optimal treatment of proximal humerus fractures remains controversial. Locking plates offer theoretical advantages but are associated with complications in the clinic. This study aimed to perform parametric design optimisation of proximal humerus plates to enhance their mechanical performance. A finite element (FE) mo...

journal_title：Annals of biomedical engineering

authors： Jabran A,Peach C,Zou Z,Ren L

更新日期：2019-02-01 00:00:00

abstract：:We propose a multiphysical mathematical model by fully coupling lipid deposition, monocytes/macrophages recruitment and angiogenesis to investigate the pathophysiological responses of an atherosclerotic plaque to the dynamic changes in the microenvironment. The time evolutions of cellular (endothelial cells, macrophag...

journal_title：Annals of biomedical engineering

authors： Guo M,Cai Y,He C,Li Z

更新日期：2019-02-01 00:00:00

abstract：:A goal of the Human Research Program at National Aeronautics and Space Administration (NASA) is to analyze and mitigate the risk of occupant injury due to dynamic loads. Experimental tests of human subjects and biofidelic anthropomorphic test devices provide valuable kinematic and kinetic data related to injury risk e...

journal_title：Annals of biomedical engineering

authors： Gaewsky JP,Jones DA,Ye X,Koya B,McNamara KP,Gayzik FS,Weaver AA,Putnam JB,Somers JT,Stitzel JD

更新日期：2019-02-01 00:00:00

abstract：:Numerous head injury models exist that vary in mesh density by orders of magnitude. A careful study of the mesh convergence behavior is necessary, especially in terms of strain most relevant to brain injury. To this end, as well as to investigate the effect of element integration scheme on simulated strains, we re-mes...

journal_title：Annals of biomedical engineering

authors： Zhao W,Ji S

更新日期：2019-02-01 00:00:00

abstract：:During defecation, solid, semisolid or liquid stools are eliminated via the anus in a complex physiological process. Up to 25% of the population are affected by anorectal disorders that are poorly recognized and treated. We developed a new bionics device, a simulated stool named Fecobionics, to replace several current...

journal_title：Annals of biomedical engineering

authors： Sun D,Huang Z,Zhuang Z,Ma Z,Man LK,Liao D,Gregersen H

更新日期：2019-02-01 00:00:00

abstract：:Blood flow simulations are making their way into the clinic, and much attention is given to estimation of fractional flow reserve in coronary arteries. Intracardiac blood flow simulations also show promising results, and here the flow field is expected to depend on the pulmonary venous (PV) flow rates. In the absence ...

journal_title：Annals of biomedical engineering

authors： Lantz J,Gupta V,Henriksson L,Karlsson M,Persson A,Carlhäll CJ,Ebbers T

更新日期：2019-02-01 00:00:00

abstract：:We and others have shown that changing surface characteristics of the spacer implanted during the first Masquelet stage alters some aspects of membrane development. Previously we demonstrated that titanium (TI) spacers create membranes that are better barriers to movement of solutes > 70 kDa in size than polymethyl me...

journal_title：Annals of biomedical engineering

authors： Toth Z,Roi M,Evans E,Watson JT,Nicolaou D,McBride-Gagyi S

更新日期：2019-01-01 00:00:00

abstract：:This experiment investigates the validity of six thermometers with different measuring sensors, operation and site of application, to estimate core temperature (Tc) in comparison to an ingestible thermometric sensor based on quartz crystal technology. Measurements were obtained before, during and after exercise in the...

journal_title：Annals of biomedical engineering

authors： Morán-Navarro R,Courel-Ibáñez J,Martínez-Cava A,Conesa-Ros E,Sánchez-Pay A,Mora-Rodriguez R,Pallarés JG

更新日期：2019-01-01 00:00:00

abstract：:Computational modeling and simulation has become more common in design and development of bioprosthetic heart valves. To have a reliable computational model, considering accurate mechanical properties of biological soft tissue is one of the most important steps. The goal of this study was to present a non-invasive mat...

journal_title：Annals of biomedical engineering

authors： Abbasi M,Barakat MS,Dvir D,Azadani AN

更新日期：2019-01-01 00:00:00

abstract：:Functional outcomes, such as joint flexion and gait, are important indicators of efficacy in musculoskeletal research. Current technologies that objectively assess these parameters, including visual tracking systems and force plates, are challenging to deploy in long-term translational and clinical studies. To that en...

journal_title：Annals of biomedical engineering

authors： Qu F,Stoeckl BD,Gebhard PM,Hullfish TJ,Baxter JR,Mauck RL

更新日期：2018-12-01 00:00:00

abstract：:While virtual reality (VR) has potential in enhancing cardiovascular diagnosis and treatment, prerequisite labor-intensive image segmentation remains an obstacle for seamlessly simulating 4-dimensional (4-D, 3-D + time) imaging data in an immersive, physiological VR environment. We applied deformable image registratio...

journal_title：Annals of biomedical engineering

authors： Abiri A,Ding Y,Abiri P,Packard RRS,Vedula V,Marsden A,Kuo CJ,Hsiai TK

更新日期：2018-12-01 00:00:00

abstract：:Spine musculoskeletal models used to estimate loads and displacements require many simplifying assumptions. We examined how assumptions about subject size and vertebral positions can affect the model outcomes. Head and neck models were developed to represent 30 subjects (15 males and 15 females) in neutral posture and...

journal_title：Annals of biomedical engineering

authors： Vasavada AN,Hughes E,Nevins DD,Monda SM,Lin DC

更新日期：2018-11-01 00:00:00

abstract：:This experimental work focused on the sensor selection for the development of a needle-like instrument to treat small isolated cartilage defects with hydrogels. The aim was to identify the most accurate and sensitive imaging method to determine the location and size of defects compared to a gold standard (µCT). Only i...

journal_title：Annals of biomedical engineering

authors： Horeman T,Buiter EC,Pouran B,Stijntjes M,Dankelman J,Tuijthof GJM

更新日期：2018-11-01 00:00:00

abstract：:Dexterity of robots is highly required when it comes to integration for medical applications. Major efforts have been conducted to increase the dexterity at the distal parts of medical robots. This paper reports on developments toward integrating biocompatible conducting polymers (CP) into inherently dexterous concent...

journal_title：Annals of biomedical engineering

authors： Chikhaoui MT,Benouhiba A,Rougeot P,Rabenorosoa K,Ouisse M,Andreff N

更新日期：2018-10-01 00:00:00

abstract：:The aim of this study was to establish in vitro bench-tests of left atrial appendage occlusion (LAAo) devices regarding tug force, radial force and sealing capacity. Two LAAo devices, namely the WATCHMAN™ and the Occlutech®, of three different sizes underwent testing in novel dedicated in vitro setups. Radial force wa...

journal_title：Annals of biomedical engineering

authors： Menne MF,Schrickel JW,Nickenig G,Al-Kassou B,Nelles D,Schmitz-Rode T,Steinseifer U,Sedaghat A

更新日期：2018-09-01 00:00:00

abstract：:Dendritic cell (DC) migration is required for efficient presentation of antigen to T cells and the initiation of an adaptive immune response. In spite of its importance, many aspects of DC migration have not been characterized. DCs encounter a variety of environments with different stiffness and geometry, but the effe...

journal_title：Annals of biomedical engineering

authors： Bendell AC,Anderson N,Blumenthal D,Williamson EK,Chen CS,Burkhardt JK,Hammer DA

更新日期：2018-09-01 00:00:00

abstract：:A search for robust noninvasive methods permitting to discern the respiration subtle peculiarities in mammals is a topical issue. A novel approach called "sorption-enhanced infrared thermography" (SEIRT), helping to solve this problem, is described. Its benefits spring from the integration of the infrared thermography...

journal_title：Annals of biomedical engineering

authors： Vainer BG

更新日期：2018-07-01 00:00:00

abstract：:Human stem cells hold significant potential for the treatment of various diseases. However, their use as a therapy is hampered because of limited understanding of the mechanisms by which they respond to environmental stimuli. Efforts to understand extracellular biophysical cues have demonstrated the critical roles of ...

journal_title：Annals of biomedical engineering

authors： Piroli ME,Jabbarzadeh E

更新日期：2018-06-01 00:00:00

abstract：:Gas transfer through hollow fiber membranes (HFMs) can be increased via fiber oscillation. Prior work, however, does not directly translate to present-day, full-scale artificial lungs. This in vitro study characterized the effects of HFM oscillations on oxygenation and hemolysis for a pediatric-sized HFM bundle. Effec...

journal_title：Annals of biomedical engineering

authors： Orizondo RA,Gino G,Sultzbach G,Madhani SP,Frankowski BJ,Federspiel WJ

更新日期：2018-05-01 00:00:00

abstract：:Glaucoma is a common optic neuropathy characterized by retinal ganglion cell death. Elevated intraocular pressure (IOP), a key risk factor for glaucoma, leads to significant biomechanical deformation of optic nerve head (ONH) cells and tissues. ONH astrocytes respond to this deformation by transforming to a reactive, ...

journal_title：Annals of biomedical engineering

authors： Mulvihill JJE,Raykin J,Snider EJ,Schildmeyer LA,Zaman I,Platt MO,Kelly DJ,Ethier CR

更新日期：2018-02-01 00:00:00

abstract：:Articular cartilage is an avascular connective tissue responsible for bearing loads. Cell signaling plays a central role in cartilage homeostasis and tissue engineering by directing chondrocytes to synthesize/degrade the extracellular matrix or promote inflammatory responses. The aim of this paper was to investigate a...

journal_title：Annals of biomedical engineering

authors： Neidlin M,Korcari A,Macheras G,Alexopoulos LG

更新日期：2018-02-01 00:00:00

abstract：:Induced pluripotent stem cell derived cardiomyocytes (iPSC-CM) provide a powerful platform for disease modeling and drug development in vitro. Traditionally, electrophysiological methods or fluorescent dyes (e.g. calcium) have been used in their functional characterization. Recently, video microscopy has enabled non-i...

journal_title：Annals of biomedical engineering

authors： Ahola A,Pölönen RP,Aalto-Setälä K,Hyttinen J

更新日期：2018-01-01 00:00:00

abstract：:Ever-increasing demand for bone grafts necessitates the realization of clinical implementation of bone tissue engineered constructs. The predominant hurdle to implementation remains to be securing FDA approval, based on the lack of viable methods for the rigorous monitoring of said constructs. The study presented here...

journal_title：Annals of biomedical engineering

authors： Simmons AD,Sikavitsas VI

更新日期：2018-01-01 00:00:00

abstract：:Dual X-ray absorptiometry (DXA) measures areal bone mineral density (aBMD) by simplifying a complex 3D bone structure to a 2D projection and is not equally effective for explaining fracture strength in women and men. Unlike DXA, subject-specific quantitative computed tomography-based finite element analysis (QCT/FEA) ...

journal_title：Annals of biomedical engineering

authors： Rezaei A,Giambini H,Rossman T,Carlson KD,Yaszemski MJ,Lu L,Dragomir-Daescu D

更新日期：2017-12-01 00:00:00

abstract：:Icariin (Ic) has been demonstrated as a potent osteoinductive compound for bone tissue engineering. However, toxic side effects of the drug and poor biocompatibility of drug delivery systems (DDSs) still limit its application for bone repair in the clinic. To overcome these disadvantages and utilize the osteoinductivi...

journal_title：Annals of biomedical engineering

authors： Li M,Zhang C,Zhong Y,Zhao J

更新日期：2017-11-01 00:00:00

abstract：:Vascular diseases are an increasing health issue, and common alloplastic, allogenic or autologous vascular grafts show frequent complications. The aim of this study is to develop an acellular, xenogenic bypass-graft from a bovine carotid artery (BAC) using detergent-based protocols. We compared decellularization with ...

journal_title：Annals of biomedical engineering

authors： Daugs A,Hutzler B,Meinke M,Schmitz C,Lehmann N,Markhoff A,Bloch O

更新日期：2017-11-01 00:00:00

abstract：:Past literature has provided evidence that a normal mechanical force environment of blood flow may guide normal development while an abnormal environment can lead to congenital malformations, thus warranting further studies on embryonic cardiovascular flow dynamics. In the current study, we developed a non-invasive 4D...

journal_title：Annals of biomedical engineering

authors： Ho S,Tan GXY,Foo TJ,Phan-Thien N,Yap CH

更新日期：2017-10-01 00:00:00

abstract：:Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to different stimuli and hypothesized as an important contributor to the mechanotransduction of wall shear stresses (WSS). In this work, ...

journal_title：Annals of biomedical engineering

authors： Cooper S,McDonald K,Burkat D,Leask RL

更新日期：2017-09-01 00:00:00

abstract：:The human thorax is commonly injured in motor vehicle crashes, and despite advancements in occupant safety rib fractures are highly prevalent. The objective of this study was to quantify the ability of gross and cross-sectional geometry, separately and in combination, to explain variation of human rib structural prope...

journal_title：Annals of biomedical engineering

authors： Murach MM,Kang YS,Goldman SD,Schafman MA,Schlecht SH,Moorhouse K,Bolte JH 4th,Agnew AM

更新日期：2017-09-01 00:00:00

abstract：:Optoelectronic plethysmography (OEP) is a noninvasive method for assessing lung volume variations and the contributions of different anatomical compartments of the chest wall (CW) through measurements of the motion of markers attached to the CW surface. The present study proposes a new method for analyzing the local C...

journal_title：Annals of biomedical engineering

authors： Solav D,Meric H,Rubin MB,Pradon D,Lofaso F,Wolf A

更新日期：2017-08-01 00:00:00

abstract：:Premature ovarian insufficiency (POI) is a major complication of cytotoxic treatments due to extreme ovarian sensitivity to chemotherapy and radiation. In pediatric cancer patients modern therapy has improved the long-term survival to over 80% in the United States. However, these cancer survivors face long-term health...

journal_title：Annals of biomedical engineering

authors： David A,Day JR,Cichon AL,Lefferts A,Cascalho M,Shikanov A

更新日期：2017-07-01 00:00:00

abstract：:Obesity is a rising issue especially in the United States that can lead to heart problems, type II diabetes, and respiratory problems. Since the 1970s, obesity rates in the United States have more than doubled in adults and children. Recent evidence suggests that exposure to certain chemicals, termed "obesogens," in u...

journal_title：Annals of biomedical engineering

authors： Wang RY,Abbott RD,Zieba A,Borowsky FE,Kaplan DL

更新日期：2017-07-01 00:00:00

abstract：:A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure-strain elastic modulus (E p). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial ar...

journal_title：Annals of biomedical engineering

authors： Yaguchi T,Cong Y,Shimo K,Kurokawa T,Sugita S,Nagayama K,Masuda H,Matsumoto T

更新日期：2017-06-01 00:00:00

abstract：:In the past decades, vascular tissue engineering has made great strides towards bringing engineered vascular tissues to the clinics and, in parallel, obtaining in-lab tools for basic research. Herein, we propose the design of a novel dual-mode bioreactor, useful for the fabrication (construct mode) and in vitro stimul...

journal_title：Annals of biomedical engineering

authors： Bono N,Meghezi S,Soncini M,Piola M,Mantovani D,Fiore GB

更新日期：2017-06-01 00:00:00